Establishing a mesenchymal stem cell bank from umbilical cord tissue for cell therapy and initial application in the treatment of knee osteoarthritis at Tam Anh general hospital

Nguyen Tam Long; Trinh Tuan Viet; Nguyen Thi Bich; Tran Thuy Duong; Nguyen Xuan Huong; Trinh Xuan Binh; Tran Thi Hoai Thanh; Tham Thi Thu Nga; Nguyen Trung  Nam

doi:10.15625/vjbt-21031

Author affiliations

Authors

Nguyen Tam Long \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0002-3084-8873
Trinh Tuan Viet \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0004-3290-7093
Nguyen Thi Bich \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0009-5348-1649
Tran Thuy Duong \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0002-6062-1872
Nguyen Xuan Huong \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0006-0802-3321
Trinh Xuan Binh \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0008-7429-8168
Tran Thi Hoai Thanh \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0009-0006-9710-4480
Tham Thi Thu Nga \(^1\) Tam Anh General Hospital, 108 Hoang Nhu Tiep Street, Bo De Ward, Long Bien District, Hanoi, Vietnam https://orcid.org/0000-0001-8396-3299
Nguyen Trung Nam \(^2\) Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/vjbt-21031

Keywords:

Stem cell bank, umbilical cord-derived mesenchymal stem cells, knee osteoarthritis

Abstract

Osteoarthritis (OA) is a natural aging process of joints that often occurs as age increases. In knee osteoarthritis, the cartilage that cushions the ends of the thigh bone and shinbone within the knee joint deteriorates, leading to a loss of cushioning and flexibility. This can result in pain, swelling, and stiffness when moving the knee joint. In the treatment of knee osteoarthritis, methods often include symptom management with pain-relieving and anti-inflammatory medications, lifestyle modifications to reduce stress on the knee joint; in some cases, surgery may be considered if nonsurgical interventions are ineffective. Stem cell therapy has emerged as a promising approach for treating knee osteoarthritis. This method has been demonstrated to be safe and effective. Still, one of the most important considerations when using stem cell therapy is quality regulation and safety standards regarding cell culture. This has led to the emergence of stem cell banks, where they are manufactured, preserved and stored. In this study, we utilized stem cells derived from allogeneic umbilical cord tissue. The stem cells were expanded and administered to patients via two injections spaced one month apart, with follow-up lasting an additional six months. The initial treatment results using stem cells for patients with knee osteoarthritis have been very promising. Through assessments of mobility, pain levels (measured by the VAS), and improvement in quality of life (measured by the Lequesne index) over 6 months, the research team has demonstrated the effectiveness of using mesenchymal stem cells (MSCs) from umbilical cord tissue for treating knee osteoarthritis.

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