Investigation of the association between the polymorphism SLC2A9 rs2280205 and gout in Vietnamese population

Author affiliations

Authors

  • Do Thi Thu Ha \(^1\) Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam https://orcid.org/0009-0009-9456-2920
  • Nguyen Phuong Anh \(^1\) Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam https://orcid.org/0009-0005-0632-5062
  • Nguyen Thy Ngoc \(^2\) University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam https://orcid.org/0000-0002-3181-9209
  • Nguyen Thuy Duong \(^1\) Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam https://orcid.org/0000-0001-8691-9138

DOI:

https://doi.org/10.15625/vjbt-19542

Keywords:

gout, PCR-RFLP, rs2280205, SLC2A9, Vietnamese

Abstract

Gout, a predominant form of inflammatory arthritis, is characterized by the deposition of uric acid crystals in joints and other tissues. Genome-wide association studies (GWAS) have established the association between gout and genetic variants of solute carrier family 2 member 9 (SLC2A9). In this study, we assessed the association of the single nucleotide polymorphism SLC2A9 rs2280205 with gout susceptibility in the Vietnamese population. Genomic DNA was extracted from the peripheral blood of 477 samples (160 gout patients and 317 healthy controls). The polymorphism rs2280205 of the SLC2A9 gene was genotyped using the PCR-RFLP method. Results indicated that the allele distribution of this variant was in accordance with Hardy-Weinberg Equilibrium, and the genotype frequencies of rs2280205 GG/GA/AA were 0.65, 0.33, and 0.02, respectively. However, no relation was identified between SLC2A9 rs2280205 and gout in this studied population. This research contributed a preliminary insight into the genetic factors in the development of gout in the Vietnamese population.

Downloads

Download data is not yet available.

Downloads

Published

30-03-2024

How to Cite

Ha, D. T. T., Anh, N. P., Ngoc, N. T., & Duong, N. T. (2024). Investigation of the association between the polymorphism <i>SLC2A9</i> rs2280205 and gout in Vietnamese population. Vietnam Journal of Biotechnology, 22(1), 133–155. https://doi.org/10.15625/vjbt-19542

Issue

Section

Articles

Most read articles by the same author(s)