Combining of silk fibroin and Aloe vera gel to fabricate wound dressings

Vu Nguyen Doan; Ha Le Bao Tran

doi:10.15625/1811-4989/15688

Author affiliations

Authors

Vu Nguyen Doan Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Vietnam National University, 227 Nguyen Van Cu Road, District 5, Ho Chi Minh City, Vietnam https://orcid.org/0000-0002-6348-7798
Ha Le Bao Tran Laboratory of Tissue Engineering and Biomedical Materials, University of Science, Vietnam National University, 227 Nguyen Van Cu Road, District 5, Ho Chi Minh City, Vietnam https://orcid.org/0000-0001-5848-1124

DOI:

https://doi.org/10.15625/1811-4989/15688

Keywords:

aloe vera gel, burn treatment, silk fibroin, wound dressing, wound healing

Abstract

Currently silk fibroin is used more and more in the biomedical researches, including a potential research direction in creating wound dressing. Aloe vera gel has been used as a traditional herbal with many properties suitable for treatment of burns such as anti-inflammatory, anti-bacterial, anti-fungal, especially improvable wound healing. Therefore, the prepared fibroin/ Aloe vera gel film (FAV) was an ideal material for wound dressings. In this study, sericin is removed from the silk to obtain fibroin fiber. Aloe vera gel is purchased from Traditional Medicine Institute, Ho Chi Minh city, Viet Nam. Fibroin fiber and Aloe vera gel are dissolved by formic acid adding calcium chloride (CaCl₂). Created FAV are then evaluated in some characteristics such as surface structure, tensile strength, absorbency, dehydration rate, biodegradation ability, preventing bacteria ability and cytotoxicity test. The results showed that FAV possessed good mechanical properties, suitable water vapor transmission rate, effective prevention of bacterial penetration and non-cytotoxic. This study is the first step to creating foundation and orientation for the development of commercial wound dressings.

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