Haplotype of \(\textit{TEX15}\) single nucleotide variants associated with male infertility in 401 Vietnamese individuals

Nguyen Phuong Anh, Bui Minh Duc, Huynh Thi Thu Hue, Nguyen Thuy Duong
Author affiliations


  • Nguyen Phuong Anh Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi, Vietnam
  • Bui Minh Duc Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi, Vietnam
  • Huynh Thi Thu Hue Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi, Vietnam
  • Nguyen Thuy Duong Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi, Vietnam; Graduate University Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Ha Noi, Vietnam




Haplotype, male infertility, PCR-RFLP, rs323347, TEX15, Vietnamese.


Spermatogenesis is a process of cell differentiation to produce fertilized sperm. Testis-expressed 15 (TEX15), an important gene in spermatogenesis, has been reported to be linked with male infertility in various populations. This study aimed to assess the association of single nucleotide polymorphism (SNP) TEX15 rs323347 with male infertile individuals in a Vietnamese cohort and further analyze the haplotypes of TEX15 rs323346 and TEX15 rs323347. A total of 401 unrelated males, including 202 male infertility patients and 199 healthy controls were genotyped for TEX15 rs323347 using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Using statistical methods, the results showed that the allele frequencies of TEX15 rs323347 were in agreement with Hardy-Weinberg equilibrium (HWE) (p-value > 0.05), but its genotype frequencies were not significantly different between male infertility patient and control groups (p-values > 0.05). However, the CA haplotype of the two variants (rs323346 and rs323347) increased the risk of male infertility (p = 0.046, OR = 2.547, 95% CI = 0.982–6.602). Thus, this study would enrich the knowledge of the impact of genetic factors on male infertility in the Vietnamese population.


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How to Cite

Nguyen, P. A., Bui, M. D., Huynh, T. T. H., & Nguyen, T. D. (2024). Haplotype of \(\textit{TEX15}\) single nucleotide variants associated with male infertility in 401 Vietnamese individuals. Academia Journal of Biology, 46(1), 13–19. https://doi.org/10.15625/2615-9023/17945




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