Efficiency of 5-pegylated pamam G4.0 as a potential nano carrier for enhancing encapsulation fluorouracil

Nguyen Thi Tram Chau, Tran Hoang Chinh, Tran Ngoc Quyen, Nguyen Cuu Khoa
Author affiliations

Authors

  • Nguyen Thi Tram Chau
  • Tran Hoang Chinh
  • Tran Ngoc Quyen
  • Nguyen Cuu Khoa

DOI:

https://doi.org/10.15625/7633

Keywords:

Dendrimer, nanocarrier, anticancer drug, 5-Flourouracil

Abstract

Polyamidoamine dendrimers are well-defined nano-structures exhibiting much cavity space inside which has been paid much attention in drug delivery. In the study, polyamidoamine dendrimer Generation 4 (PAMAM G4) was pegylated by nitrophenyl chloroformate-activated polyethylene glycol 4000-tyramine (NPC-PEG-TA). The pegylated dendrimer was characterized by NMR, FT-IR, GPC, and TEM, which revealed that G4-PEG4K’ MW is about 147,980 Da, and its size is ranging from 70 to 80 nm in diameter. The capacity of G4-PEG4K nanocarrier was evaluated in order to loading 5-Flourouracil (5-Fu) anticancer drug using HPLC. The results showed that G4-PEG4K can load 8.84 wt/wt% of the drug which is higher than that of G3-MPEG (around 6.28 wt/wt%). According this result, we can suggest that G4-PEG4K could be an effective nanocarrier for drug encapsulation.

Keywords. Dendrimer, nanocarrier, anticancer drug, 5-Flourouracil.

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Published

01-12-2015

How to Cite

Tram Chau, N. T., Chinh, T. H., Quyen, T. N., & Khoa, N. C. (2015). Efficiency of 5-pegylated pamam G4.0 as a potential nano carrier for enhancing encapsulation fluorouracil. Vietnam Journal of Chemistry, 53(5), 630. https://doi.org/10.15625/7633

Issue

Vol. 53 No. 5 (2015)

Section

Articles