Anticaries activity of mangiferin isolated from Mangifera indica leaves in Vietnam
Author affiliations
DOI:
https://doi.org/10.15625/2525-2321.2017-00519Keywords:
Mangifera indica, mangiferin, Streptococcus mutans, anticaries activityAbstract
Mangiferin (1) was isolated from Vietnamese Mangifera indica leaves. Its antimicrobial activities against the oral bacterium Streptococcus mutans GS-5 were evaluated in terms of inhibition of acid production and biofilm formation. The obtained results indicated that mangiferin at the concentration of 0.5 mM clearly inhibited acid production by this organism with a final pH value of 5.2 compared to 3.9 of the control. The reduction in biofilm biomass was found up to 92 % when it was treated with 1.0 mM mangiferin. Thus, mangiferin possesses moderate anticaries activity against S. mutans GS-5.
Keywords. Mangifera indica, mangiferin, Streptococcus mutans, anticaries activity.
Downloads
References
M. Javed, S. Chaudhry, S. Butt, S. Ijaz, R. Asad, F. Awais, and A. Khan. Transmission of Streptococcus mutans from Mother to Child, Pakistan Oral & Dental 32(3), Web. 24 Jul 2013.
T. Kabuki, H. Nakajima, M. Arai, S. Ueda, Y. Kuwabara, S. Dosako. Characterization of novel antimicrobial compounds from mango (Mangifera indica L.) kernel seeds, Food Chemistry, 71, 61-66 (2010).
M. S. Latha, K. P. Latha, H. M. Vagdevi, B. S. Virupaxappa, A. S. Nagashree. Phytochemical investigation and antibacterial activity of Mangifera indica L. Varrasapuriroots extract, Journal of Medicinal and Aromatic Plants, 1(2), 45-47 (2011).
W. A. Belli, R. E. Marquis. Adaptation of Streptococcus mutans and Enterococcus hirae to acid stress in continuous culture, Appl. Environ. Microbiol., 57, 1134-1138 (1991).
H. Koo, J. G. Jeon. Naturally occurring molecules as alternative therapeutic agents against cariogeneric biofilms, Adv. Dent. Res., 21, 63-68 (2009).
P. T. M. Nguyen, M. L. Falsetta, G. Hwang, M. Gonzalez, H. Koo. α-Mangostin disrupts the development of Streptoccocus mutans biofilms and facilitates its mechanical removal, Plos One, 9(10), e111312 (2014).
H. Koo, J. Xiao, M. I. Klein. Extracellular polysaccharides matrix--an often forgotten virulence factor in oral biofilm research, Int. J. Oral. Sci., 1(4), 229-34 (2009).
C. Pierre, Djemgou, T. A. Hussien, F. H. Mohamed-Elamir, F. Ngandeu, G. Neguim, P. Tane, A. H. Mohamed. C-glucoside xanthone from the stem bark extract of Bersama engleriana, Pharmacognosy, 2(4), 229-232 (2010).
