Synthesis and bioactivity evaluation of 2-aza-anthraquinones
Nguyen Van TuyenPham The ChinhLe Nhat Thuy GiangVu Thi Thu HaDang Thi Tuyet AnhHoang Thi PhuongNguyen Ha ThanhPham Thi ThamNguyen Quang Trung
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DOI:
https://doi.org/10.15625/0866-7144.2016-00398Keywords:
Synthesis, 2-aza-anthraquinones, bioactivity, benz[g]isoquinoline.Abstract
2-Aza-anthraquinones can be found in nature. Many of these azaanthraquinones derivatives have indeed been discovered to possess diverse and pronounced biological activities, including antimicrobial, antiparasitic, antiviral and anticancer properties. These compounds have been shown to be an intercalating agent to DNA. In continuation of our synthetic interest in physiologically active quinone derivatives, the present report describes the synthesis and bioactivity evaluation of 2-aza-anthraquinones. The biological assessment of all these compounds demonstrated a significant cytotoxic effect of 2-azaanthraquinones against different cancer cell lines.Downloads
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Published
28-12-2016
How to Cite
Tuyen, N. V., Chinh, P. T., Thuy Giang, L. N., Thu Ha, V. T., Tuyet Anh, D. T., Phuong, H. T., Thanh, N. H., Tham, P. T., & Trung, N. Q. (2016). Synthesis and bioactivity evaluation of 2-aza-anthraquinones. Vietnam Journal of Chemistry, 54(6), 747. https://doi.org/10.15625/0866-7144.2016-00398
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