Synthesis of 8-methyl-2-O-methyl-3,5-O-(1-methyl ethylidene)-6,7,8,9-tetradeoxy-D-gulo-6-nonenonic acid (6E)- -lactone

Phi Thi Dao, Doan Thi Mai Huong, Le Thi Phuong, Chau Van Minh, Pham Van Cuong
Author affiliations

Authors

  • Phi Thi Dao Nhà xuất bản Khoa học Tự nhiên và Công nghệ
  • Doan Thi Mai Huong
  • Le Thi Phuong
  • Chau Van Minh
  • Pham Van Cuong

DOI:

https://doi.org/10.15625/6890

Keywords:

Bengamide, synthesis analogues antitumor

Abstract

Ketide side chain, 8-methyl-2-O-methyl-3,5-O-(1-methylethylidene)-6,7,8,9-tetradeoxy-D-gulo-6-nonenonic acid (6E)-γ-lactone was synthesized starting from the commercial available α-D-glucoheptonic γ-lactone. The synthesis is useful for further synthesis of new and stable bengamide analogues containing an additional methyl group at C-8. The structures of synthetic compounds were determined by spectroscopic analysis, including MS and NMR.

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Published

04-09-2015

How to Cite

Dao, P. T., Mai Huong, D. T., Phuong, L. T., Minh, C. V., & Cuong, P. V. (2015). Synthesis of 8-methyl-2-O-methyl-3,5-O-(1-methyl ethylidene)-6,7,8,9-tetradeoxy-D-gulo-6-nonenonic acid (6E)- -lactone. Vietnam Journal of Chemistry, 53(2e). https://doi.org/10.15625/6890

Issue

Vol. 53 No. 2e (2015)

Section

Articles