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Approach to synthesis of prednisolone from 9α-hydroxy androstenedione

Luu Duc Huy, Nguyen Thi Diep, Lee Chang-Hee, Nguyen Duc Hung


In this report we showed an efficient approach to synthesis of prednisolone from 9α-hydroxy androst-4-ene-3,17-dione via 16α,17α-epoxy-pregn-4,9(11)-diene-21-ol-3,20-dione. Structure of obtained products has been studied by spectral methods such as IR, MS, NMR.

Keywords: 9α-hydroxy androst-4-ene-3,17-dione,16α,17α-epoxy- pregn-4,9(11)-diene-21-ol-3,20-dione.


9α-hydroxy androst-4-ene-3,17-dione,16α,17α-epoxy- pregn-4,9(11)-diene-21-ol-3,20-dione