Triterpenes from Vitex limonifolia.

Nguyen Thi Kim Thoa, Ninh Khac Ban, Do Thi Trang, Tran My Linh, Vu Huong Giang, Nguyen Xuan Nhiem, Phan Van Kiem

Abstract


Using combined chromatographic methods, four triterpenoids, 2α,3α-dihydroxyurs-12-en-28-oic acid (1), euscaphic acid (2), 2α,3α-dihydroxy-19-oxo-18,19-seco-urs-11,13(18)-dien-28-oic acid (3), and maslinic acid (4) were isolated from the methanol extract of the leaves of Vitex limonifolia. Their structures were elucidated by 1D-, 2D-NMR spectra as well as by comparison with those reported in the literature. Compound 3 was reported from Vitex genus for the first time.

Keywords. Vitex limonifolia, triterpenoid, ursane, oleanane.


Keywords


Vitex limonifolia, triterpenoid, ursane, oleanane

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References


A. Rani, A. Sharma. The genus Vitex: a review. Pharmacognosy Reviews, 7, 188-198 (2013).

S. Ganapaty, K. N. Vidyadhar. Phytoconstituents and biological activities of Vitex-a review. Journal of Natural Remedies, 5, 75-95 (2005).

J. -J. Cheng, L. -J. Zhang, H. -L. Cheng, C. -T. Chiou, I. J. Lee, Y.-H. Kuo. Cytotoxic hexacyclic triterpene acids from Euscaphis japonica, Journal of Natural Products, 73, 1655-1658 (2010).

Hisashi Kojima, H. Ogura. Triterpenenoids from Prunella vulgaris, Phytochemistry, 25(3), 729-733 (1986).

C. Sridhar, K. V. Rao, G. V. Subbaraju. Flavonoids, triterpenoids and a lignan from Vitex altissima, Phytochemistry, 66, 1707-1712 (2005).

M. M. Li, X. Q. Su, J. Sun, Y. F. Gu, Z. Huang, K. W. Zeng, Q. Zhang, Y. F. Zhao, D. Ferreira, J. K. Zjawiony, J. Li, P. F. Tu. Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia, Journal of Natural Products, 77, 2248-2254 (2014).

H. Ping, K. Gloria, W. Shanxin, W. Peter. Triterpene acids from Toddalia asiatica, Natural Product Research and Development, 17, 404-408 (2005).

S. Taniguchi, Y. Imayoshi, E. Kobayashi, Y. Takamatsu, H. Ito, T. Hatano, H. Sakagami, H. Tokuda, H. Nishino, D. Sugita, S. Shimura, T. Yoshida. Production of bioactive triterpenes by Eriobotrya japonica calli, Phytochemistry, 59, 315-

(2002).

C. -J. Zheng, B. -K. Huang, Y. -B. Wu, T. Han, Q. -Y. Zhang, H. Zhang, L. -P. Qin. Terpenoids from Vitex negundo seeds, Biochemical Systematics and Ecology, 38, 247-249 (2010).