Nghiên cứu điều chế hydrogel nhạy nhiệt trên cơ sở copolyme ghép chitosan-pluronic F127 định hướng ứng dụng trong chữa lành vết thương

Nguyễn Thị Bích Trâm, Đặng Thị Lệ Hằng, Lê Thị Thu Thắm, Nguyễn Đại Hải, Nguyễn Cửu Khoa, Trần Ngọc Quyển

Abstract


In recent years, injectable chitosan-based hydrogels have been widely studied towards biomedical applications because of their potential performance in drug/cell delivery and tissue regeneration. In this study, a temperature-sensitive bio-hydrogel based on chitosan and pluronic was synthesized. The structure of copolymer was characterized by IR and 1H-NMR spectroscopy. The sol-gel phase transition behavior of hydrogel was rheology method. The in vitro experiments showed that, the solutions of chitosan-pluronic F127 were changed to gel stage to gel stage when the temperature increased from 25 oC to 40 oC. The result is a prerequisite for the interesting studies of this complex hydrogel.

Keywords


Thermosensitive hydrogel, chitosan, pluronic, wound healing.

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