Các hợp chất thứ cấp từ chủng xạ khuẩn biển Micromonospora sp. (G043)

Cao Đức Tuấn, Trần Văn Hiệu, Đoàn Thị Mai Hương, Vũ Thị Quyên, Lê Thị Hồng Minh, Brian Murphy, Châu Văn Minh, Phạm Văn Cường

Abstract


Analysis of an antimicrobial extract prepared from culture broth of the marine-derived actinomycete Micromonospora sp. (strain G043) led to the isolation of 9 secondary metabolites and identified as Cyclo-(Pro-Leu) (1), Cyclo-(Pro-Val) (2), Cyclo-(Pro-Trp) (3), Cyclo-(Pro-Phe) (4), Cyclo-(Pro-Tyr) (5), and Cyclo-(Leu-Tyr) (6), 2-phenylacetic acid (7), N-(4-hydroxyphenylethyl)acetamide (8), bis(2-ethylhexyl) adipate (9). The structures of 1-9 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 3, 6 and 7 inhibited Escherichia coli with a MIC value of 128, 32 and 32 µg/ml, respectively.

Keywords


Micromonospora sp. (G043 strain), marine microorganism, cyclodipeptide, antimicrobial activity.

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