Synthesis and biological evaluation of 2-aryl-4-aminoquinazolines as antitumor agents

Le Nguyen Thanh, Tran Huu Giap, Nguyen Anh Dung, Vu Thi Mung, Van Thi My Hue, Nguyen Thi Minh Hang, Chau Van Minh, Won-Jea Cho
Author affiliations

Authors

  • Le Nguyen Thanh Nhà xuất bản Khoa học Tự nhiên và Công nghệ
  • Tran Huu Giap
  • Nguyen Anh Dung
  • Vu Thi Mung
  • Van Thi My Hue
  • Nguyen Thi Minh Hang
  • Chau Van Minh
  • Won-Jea Cho

DOI:

https://doi.org/10.15625/0866-7144.2015-2e-013

Keywords:

Anticancer, 3-arylisoquinolinamine, 2-aryl-4-aminoquinazolines.

Abstract

Quinazoline is an important pharmacophore, showing many biological activities. Some novel 2-aryl-4-aminoquinazolines were designed from 3-arylisoquinoline-1-amines using bioisostere approach. The 4-aminoquinazoline derivatives were prepared from corresponding quinazolinones in 3 steps. The cytotoxicity of these compounds was evaluated against 4 cancer cell lines including human epidermic carcinoma (KB), hepatocellular carcinoma (Hep-G2),  human lung carcinoma (LU-1) and human breast carcinoma (MCF-7). Quinazolineamine compound 4a showed good antitumor activity on KB cell line.

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Published

16-07-2015

How to Cite

Thanh, L. N., Giap, T. H., Dung, N. A., Mung, V. T., My Hue, V. T., Minh Hang, N. T., Minh, C. V., & Cho, W.-J. (2015). Synthesis and biological evaluation of 2-aryl-4-aminoquinazolines as antitumor agents. Vietnam Journal of Chemistry, 53(2e), 56–60. https://doi.org/10.15625/0866-7144.2015-2e-013

Issue

Vol. 53 No. 2e (2015)

Section

Articles