A practical synthesis of fluoroquinolone antibiotic moxifloxacin

Le Nguyen Thanh, Tran Huu Giap, To Hai Tung, Nguyen Anh Dung, Van Thi My Hue, Cao Thi Hue, Nguyen Thi Minh Hang, Nguyen Van Hung, Chau Van Minh
Author affiliations

Authors

  • Le Nguyen Thanh Nhà xuất bản Khoa học Tự nhiên và Công nghệ
  • Tran Huu Giap
  • To Hai Tung
  • Nguyen Anh Dung
  • Van Thi My Hue
  • Cao Thi Hue
  • Nguyen Thi Minh Hang
  • Nguyen Van Hung
  • Chau Van Minh

DOI:

https://doi.org/10.15625/0866-7144.2015-2e-012

Keywords:

Fluoroquinolone, antibiotic, moxifloxacin

Abstract

The fluoroquinoloneantibiotic has been used in clinical practice since the 1980s, primarily for the treatment infections caused by Gram-negative bacteria. Moxifloxacin, a fourth-generation fluoroquinolone antibiotic developed by pharmaceutical company Bayer AG, exhibit broad spectrum of activity against Gram-negative, Gram-positive bacteria as well as  anaerobia. Moxifloxacin is used for community-acquired respiratory tract infections, sinusitis, acute exacerbations of chronic bronchitis and pneumonia, and skin structure infections. We have described the synthesis of moxifloxacin using difluoroboron complex. In this paper, a practical synthesis of moxifloxacin using acetoxyboronate complexwas reported.

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Published

21-05-2015

How to Cite

Thanh, L. N., Giap, T. H., Tung, T. H., Dung, N. A., My Hue, V. T., Hue, C. T., Minh Hang, N. T., Hung, N. V., & Minh, C. V. (2015). A practical synthesis of fluoroquinolone antibiotic moxifloxacin. Vietnam Journal of Chemistry, 53(2e), 52–55. https://doi.org/10.15625/0866-7144.2015-2e-012

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Articles