Hợp chất lignan glycosid mới từ cây bù dẻ râu Uvaria fauveliana

Hồ Việt Đức, Nguyễn Thị Hoài, Đỗ Thị Thảo, Bùi Hữu Tài, Châu Văn Minh, Phan Văn Kiệm
Author affiliations

Authors

  • Hồ Việt Đức
  • Nguyễn Thị Hoài
  • Đỗ Thị Thảo
  • Bùi Hữu Tài
  • Châu Văn Minh
  • Phan Văn Kiệm

DOI:

https://doi.org/10.15625/0866-7144.2014-0013

Keywords:

Uvaria fauveliana, lignan glycoside, cytotoxicity

Abstract

Chemical investigation of the aerial parts of Uvaria fauveliana yielded one new lignan glycoside, (8S,8’S)-4,4’-dihydroxy-3,5,3’,5’-tetramethoxy-8,8’-butyrolignan 9-O-α-L-rhamnopyranoside (1), along with two known compounds, oxoanolobine (2) and ergosta-4,6,8(14),22-tetraen-3-one (3). Their chemical structures were established by NMR, HR-MS analysis and in comparison with the reported data. Compounds 2 and 3 displayed moderate cytotoxicity against human lung adenocarcinoma cancer cell line (LU-1) with IC50 values of 9.22±1.02, 10.21±1.16 μg/mL, respectively.

Keywords: Uvaria fauveliana, lignan glycoside, cytotoxicity.

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Published

17-09-2014

How to Cite

Đức, H. V., Hoài, N. T., Thảo, Đỗ T., Tài, B. H., Minh, C. V., & Kiệm, P. V. (2014). Hợp chất lignan glycosid mới từ cây bù dẻ râu Uvaria fauveliana. Vietnam Journal of Chemistry, 52(4), 463. https://doi.org/10.15625/0866-7144.2014-0013

Issue

Vol. 52 No. 4 (2014)

Section

Articles