Enantioselective separation of ofloxacin by ligand exchange chromatography

Nguyen Tien Dat, Nguyen Quoc Vuong, Tran Thi Hong Hanh
Author affiliations

Authors

  • Nguyen Tien Dat Nhà xuất bản Khoa học Tự nhiên và Công nghệ
  • Nguyen Quoc Vuong
  • Tran Thi Hong Hanh

DOI:

https://doi.org/10.15625/6639

Keywords:

Ofloxacin, levofloxacin, ligand exchange HPLC, enantio selective separation

Abstract

A ligand exchange HPLC method for enantioseparation of ofloxacin enantiomers was developed by a using C8 stationary phase. Chromatographic separation was performed on a Zorbax-300SB-C8 column eluted with the mobile phase consisting of 15 % methanol in water containing 10mM phenylalanin and 5 mM CuSO4 at flow rate of 0.8 mL/min. The method was simple, rapid and suitable for routine analytical studies of ofloxacin enantiomers.

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Published

31-07-2015

How to Cite

Dat, N. T., Vuong, N. Q., & Hong Hanh, T. T. (2015). Enantioselective separation of ofloxacin by ligand exchange chromatography. Vietnam Journal of Chemistry, 53(2e), 65–68. https://doi.org/10.15625/6639

Issue

Vol. 53 No. 2e (2015)

Section

Articles