Further chemical constituents of Scoparia dulcis L. (Scrophulariaceae) originating in Vietnam

Abstract

Palmitic acid (1), b-sitosterol (2), glutinol (3), and a mixture of b-amyrin (4) and isomultiflorenol (5), whose structures were determined by using spectroscopic methods, were isolated from the aerial parts of Scoparia dulcis L. (Scrophulariaceae). The volatile fraction of S. dulcis was analyzed by GC-MS to show the accumulation of methyl esters of fatty acids. The useful compound methoxybenzoxazolinone (MBOA) was found to be localized in the CH₂Cl₂-soluble fraction of the MeOH extract. For the direct qualitative and quantitative evaluation of MBOA in the CH₂Cl₂-soluble fraction ¹H-NMR method was applied in this study. Antimicrobial test of the soluble fractions and MBOA showed inhibition on Escherichia coli, Pseudomonas aeruginosa, and Saccharomyces cerevisiae.

Keywords: Scoparia dulcis; Scrophulariaceae; triterpenoid; methoxybenzoxazolinone (MBOA).