Tổng hợp toàn phần ancaloit vincadiformin

Abstract

Based on the A. I. Scott_,s hypothesis for biosynthesis of indole alkaloids in the plants, by the chemical methods we had succesfully total synthesized the3-oxo-vincadifformine (5) from 2-ethoxycarbonyl-tripthamine (2) via compound 3 and 3-oxo-secodine (4). With the intermolecular cyclisation of the key intermediate 4 the 3-oxo-vincadifformine (5) was formed and then by selective reduction of the C=O amide in compound 5 into CH₂.group afforded vincadifformine (1).