Nghiên cứu chuyển hóa 3-oxominovin thành ancaloit minovin

Abstract

Minovine (1), an alkaloid of Vinca minor, was prepared by transformation of 3-oxominovine (3) is threes steps: The first the compound 3 was reacted with P₂O₅ into 3-thioxo-minovine (4),  methylattion of that gave the salt 5 and in the end this product was reduced with NaBH4 to form minovine (1).