ĐIỀU CHẾ VÀ TÍNH CHẤT CỦA 5-(4-AXETAMIDO-2-CLOARYL)-1,3,4-OXADIAZOL-2-THIOL

Abstract

Thiocarbamoylation 4-acetamido-2-chlorobenzoyl hydrazide by tetramethylthiuram disulphide (TMTD) afforded 5-(4-acetamido-2-chlorophenyl)-1,3,4-oxadiazole. Reaction of the later with  N-a-cloacetanilide derivatives run into two alternative ways. In the alkaline solution 2-arylamino-5-(acetamido-2-chlorophenyl)-1,3,4-oxadiazole has been isolated, but in the neutral medium 2-(N-carboxamidoarylmethylthio)-5-(4-acetamido-2-chlorophenyl)-1,3,4-oxadiazole have been obtained as the main product.  The structures of the products have been confirmed by the spectroscopic data and the biological activities have been tested.