Enantioselective separation of ofloxacin by ligand exchange chromatography
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DOI:
https://doi.org/10.15625/6639Keywords:
Ofloxacin, levofloxacin, ligand exchange HPLC, enantio selective separationAbstract
A ligand exchange HPLC method for enantioseparation of ofloxacin enantiomers was developed by a using C8 stationary phase. Chromatographic separation was performed on a Zorbax-300SB-C8 column eluted with the mobile phase consisting of 15 % methanol in water containing 10mM phenylalanin and 5 mM CuSO4 at flow rate of 0.8 mL/min. The method was simple, rapid and suitable for routine analytical studies of ofloxacin enantiomers.
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Published
31-07-2015
How to Cite
Dat, N. T., Vuong, N. Q., & Hong Hanh, T. T. (2015). Enantioselective separation of ofloxacin by ligand exchange chromatography. Vietnam Journal of Chemistry, 53(2e), 65–68. https://doi.org/10.15625/6639
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