TY - JOUR AU - Hai Ha, Pham Thi AU - Kien Cuong, Tran AU - Thu Nha, Nguyen Thi AU - Hoang Lan, Nguyen Phan AU - Thuan Anh, Nguyen Huu AU - Long Giang, Bach AU - Minh Quan, Pham AU - Quoc Toan, Tran AU - Quoc Long, Pham AU - Thanh Luan, Nguyen PY - 2022/06/30 Y2 - 2024/03/29 TI - A study on biological activities of Bouea macrophylla Griff leaf extract JF - Vietnam Journal of Biotechnology JA - Vietnam J. Biotechnol. VL - 20 IS - 2 SE - Articles DO - 10.15625/1811-4989/16059 UR - https://vjs.ac.vn/index.php/vjbt/article/view/16059 SP - 339-349 AB - <p><em>Bouea macrophylla </em>in the family Anacardiaceae is a prominent fruit in Southeast Asia, especially in Vietnam with several prospects. This study focused on the bioactive components and biological effects of <em>B. macrophylla </em>ethanol leaf extract<em>. </em>Phytochemical analysis revealed various compounds including polyphenol, tannin, saponin, reducing agent, flavonoid, and essential oil in the extract. The DPPH assay showed the remarkable antioxidant capacity of the extract (IC<sub>50</sub> = 6.4 ± 0.08 μg/ml), which is stronger than ascorbic acid (IC<sub>50 </sub>= 9.35 ± 0.12 μg/ml). The disc diffusion method and minimal inhibitory concentration test displayed the significant antibacterial ability of the extract against <em>Listeria monocytogenes</em>, <em>Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, </em>and <em>Bacillus cereus </em>at the range from 10 - 15 mg/ml, but no activity against <em>Staphylococcus aureus</em>. Moreover, the MTT assay was performed the noticeable anticancer activity of the extract in HepG2 (IC<sub>50 </sub>= 72.33 ± 0.68 μg/ml), and MCF-7 cells (IC<sub>50 </sub>= 50.25 ± 1.36 μg/ml). Taken together, this study indicated the effects of <em>B. macrophylla</em> ethanol leaf extract from Vinh Long Province, Vietnam on antibacterial, antioxidant, and anticancer properties. Therefore, <em>B. macrophylla</em> possibly is used in the food industry and medicine.</p> ER -