TY - JOUR AU - Duc, Le Hoang AU - Trung Nam, Nguyen PY - 2021/10/13 Y2 - 2024/03/29 TI - Ahr and CYP1B1 gene expression in type 2 diabetes patients in Vietnam JF - Vietnam Journal of Biotechnology JA - Vietnam J. Biotechnol. VL - 19 IS - 3 SE - Articles DO - 10.15625/1811-4989/15000 UR - https://vjs.ac.vn/index.php/vjbt/article/view/15000 SP - 441-447 AB - <p>Type 2 diabetes is a chronic disease, which has risen dramatically in many countries in the world, including Vietnam. Recently, there is increasing evidence about the link between type 2 diabetes and the exposure to <em>Ahr </em>ligands such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the experimental animal model. In the cell, after activation by the ligands, <em>Ah</em><em>r</em> moves from the cytoplasm into the nucleus and binds to the nuclear translocator, resulting in transcription of target genes such as <em>Cyp1b1</em>. The development of type 2 diabetes was shown in some people who exposed to TCDD. However, the role of <em>Ahr</em><em>/Cyp1b1</em> genes in type 2 diabetes patients has not been elucidated. In this study, the expression of the <em>Ahr</em> and <em>Cyp1b1</em> genes in blood samples collected from patients with type 2 diabetes and controls was studied for the first time in Vietnam. Analysis of blood glucose showed that this index in the type 2 diabetes patients was higher than that in the control group. Using real-time PCR method, the results showed that the expression of <em>Ahr</em> and <em>Cyp1b1</em> in type 2 diabetes patients was significantly higher than that in control group. In addition, the expression of <em>Ahr</em> and <em>Cyp1</em><em>b</em><em>1</em> was positively correlated with the blood glucose levels of both groups. These results are initial evidence for the link between activation of <em>Ahr</em>/<em>Cyp1b1</em> signaling pathway and level of blood glucose so that <em>Ahr</em>/<em>Cyp1b1 </em>genes can be potential targets to treat type 2 diabetes.</p> ER -