@article{Phuong Ha_Van Ngoc_Trang Huyen_Thu Hang_Kieu Oanh_Tuyet_Mai Phuong_Minh Hong_2022, title={Total phenolic, flavonoid contents and antioxidant activity of tamarind seed and pulp extracts}, volume={20}, url={https://vjs.ac.vn/index.php/vjbt/article/view/15930}, DOI={10.15625/1811-4989/15930}, abstractNote={<p>Tamarind (<em>Tamarindus indica</em>) has long been known for its high nutrition content and pharmacological potential. However, there is lack of studies on the content of antioxidants, phenolic and flavonoid contents of tamarind seed grown in Vietnam. Thus, the aim of this study was to compare the seeds and pulps of <em>Tamarindus indica</em> from three different areas across Vietnam including Son La, Hai Phong and Sai Gon with regard to the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of their water and methanol extracts, as well as their cytotoxicity on a normal BKH-21cells. TPC and TFC were evaluated by the Folin–Ciocalteu reagent and aluminum chloride, respectively. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assays were used to investigate antioxidant capacity. The safety of <em>T. indica</em> extracts was assessed by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Our results showed that the methanolic extracts yielded higher TPC (742.919 ± 50.360 mg GAE/g extract), TFC (68.492 ± 0.023 mg QE/g extract) and possessed stronger free radical scavenging activity (IC<sub>50</sub> of 52.5 µg/mL) compared to that of water extracts. <em>T. indica</em> seeds from all three regions possessed higher TPC, TFC and antioxidant activity than those of pulps. Regarding the safety, <em>in vitro</em> analysis showed that tamarind seed and pulp extracts only became toxic to BHK-21 cell line at a very high concentration with IC<sub>50</sub> values range from 143.77 µg/mL to 620.35 µg/mL. This study revealed that <em>T. indica</em> seeds and pulps can serve as functional food as well as potential antioxidants in pharmaceutical products.</p>}, number={2}, journal={Vietnam Journal of Biotechnology}, author={Phuong Ha, Le and Van Ngoc, Nguyen and Trang Huyen, Nguyen Thi and Thu Hang, Le Thi and Kieu Oanh, Nguyen Thi and Tuyet, Tran Thi and Mai Phuong, Nguyen Thi and Minh Hong, Nguyen Thi}, year={2022}, month={Jun.}, pages={305–316} }