New inhibitors for dicarbonyl/L-xylulose reductase in Caenorhabditis elegans

Le Tho Son, Nguyen Hai Dang, Lai Thi Phuong, Nguyen Thi Thu, Nguyen Huy Hoang
Author affiliations

Authors

  • Le Tho Son College of Forestry Biotechnology, Vietnam National University of Forestry, Xuan Mai Town, Chuong My District, Hanoi, Vietnam https://orcid.org/0000-0002-7580-9301
  • Nguyen Hai Dang College of Forestry Biotechnology, Vietnam National University of Forestry, Xuan Mai Town, Chuong My District, Hanoi, Vietnam
  • Lai Thi Phuong Department of Fishery Technology, Vocational Technology, Economy and Fishery College, 804 Thien Loi, Le Chan District, Hai Phong, Vietnam
  • Nguyen Thi Thu Mathematics Department, F-School, Vietnam National University of Forestry, Xuan Mai Town, Chuong My District, Hanoi, Vietnam
  • Nguyen Huy Hoang Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/1811-4989/16673

Abstract

Dicarbonyl/L-xylulose reductase (DCXR) is an enzyme reducing dicarbonyl (-CO-) groups in single sugar molecules and participates in the sugar metabolism of several sugar metabolism cycles in different living organisms (humans, other animals, fungi, and microorganisms). Caenorhabditis elegans, a model organism, has a unique DCXR (referred to as Ce DCXR) which plays a biochemical function similar to its homologs in the other organisms. However, the catalytic regulation of the enzyme has not been fully elucidated yet. Therefore, in this study, we investigated the chemicals which could inhibit the enzyme and found three inhibitor compounds including hexanoic acid, phosphoenolpyruvic acid, and DL-α-aminobutyrate hydrochloride for the enzyme. Because these inhibitors and their derivatives suppressed DCXRs in humans, mice, rabbits, and rats, they possibly inhibit the DCXR homologs at least in other animals. If the inhibitors and their derivatives are components in pharmaceutical products, foods, and drinks, they may come into cells, interact with DCXRs and inactivate them, causing toxicity for the host organisms.

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Published

30-09-2022

How to Cite

Tho Son, L., Hai Dang, N., Thi Phuong, L., Thi Thu, N., & Huy Hoang, N. (2022). New inhibitors for dicarbonyl/L-xylulose reductase in Caenorhabditis elegans. Vietnam Journal of Biotechnology, 20(3), 517–526. https://doi.org/10.15625/1811-4989/16673

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Articles