Academia Journal of Biology
https://vjs.ac.vn/index.php/vjbio
<p><strong><em>Academia Journal of Biology </em>(AJB)<em>, </em></strong>ISSN (print) 2615-9023, ISSN (online) 2815-5920, has been indexed on Master Journal List of Web of Science <a href="https://mjl.clarivate.com/search-results">https://mjl.clarivate.com/search-results</a>, and indexed on Asean Citation Index (ACI) <a href="https://asean-cites.org/list_of_journal.html">https://asean-cites.org/list_of_journal.htm</a>. The Academia Journal of Biology is a peer-reviewed for rapid publication of articles on all aspects of biology including: Biodiversity, biochemistry, biogeography, biophysics, biotechnology, botany, conservation, ecology, entomology, environment, evolution, fishery, genetics, herpetology, microbiology, mammalogy, morphology, ornithology, parasitology, physiology, systematics, taxonomy, and zoology. The AJB publishes 4 issues per year with an entire English and average number of research articles published from 53 to 55 articles/year and from 13 to 14 articles/per issue. The journal welcomes three article types: research article, review articles, and short communications. Each manuscript will be reviewed by confidential peer reviewers before acceptance. There are no fees for publishing articles or other publishing related fees. All cost for the publication process is supported by the Vietnam Academy of Science and Technology. Please read more about submitting a manuscripts in the <a href="https://vjs.ac.vn/index.php/vjbio/about/submissions#authorGuidelines"><strong>Author Guidelines</strong></a>.</p> <p><em>Academia Journal of Biology</em> is an open access and peer-reviewed journal. All academic publications could be made free to read and download for everyone.</p> <p><em>Academia Journal of Biology</em> commits to publishing rapidly every accepted manuscript, within 30 days after acceptance by the Editor-in-Chief.</p> <ul> <li><a href="https://vjs.ac.vn/index.php/vjbio/about/submissions#onlineSubmissions">Online Submissions</a></li> <li><a href="https://vjs.ac.vn/index.php/vjbio/about/submissions#authorGuidelines">Author Guidelines</a></li> <li><a href="https://vjs.ac.vn/index.php/vjbio/about/submissions#copyrightNotice">Copyright Notice</a></li> </ul>Publishing House Science and Technology, VASTen-USAcademia Journal of Biology2615-9023New record and redescription of <i>Microcotyle helotes</i> Sandars, 1944 (Monogenea: Microcotylidae) in Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/19870
<p>Twenty-seven specimens of the fish species <em>Terapon jarbua</em> and 4 specimens of the fish species <em>Terapon theraps</em> were collected from the Cat Ba Archipelago marine area, and examined for parasite infection. Among these, 4 specimens of <em>T. jarbua</em> and 1 specimen of <em>T. theraps</em> were infected with a total of 42 monogeneans. The intensity of infection ranged from 1 to 16 worms per fish. Four monogenean species were identified, three of which belong to the Protogyrodactylidae: <em>Protogyrodactylus gussevi </em>(14 specimens) and <em>Protogyrodactylus perforatus</em> (12 specimens) were found on <em>T. jarbua</em>, while <em>Protogyrodactylus solidus</em> (1 specimen) was identified on <em>T. theraps</em>. The species <em>Microcotyle helotes</em> (17 specimens) was recorded for the first time in Vietnam, found in two individuals of the new host <em>T. jarbua</em>. Additionally, a redescription of <em>M. helotes</em> was provided.</p>Ha Hoang Thi NguyenHa Van NguyenManh Hung Nguyen
Copyright (c) 2024 Nguyen Thi Hoang Ha, Nguyen Van Ha, Nguyen Manh Hung
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2024-06-232024-06-234621610.15625/2615-9023/19870Combining morphological and molecular data to identify <i>Padina</i> seaweed samples collected from Hon Thom, Phu Quoc in Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/20583
<p>The <em>Padina </em>genus has 75 species of which 54 species are classification recognized. The<em> Padina </em>genus has been used as nutritional food that supplies vitamins, proteins, and carotenoids by humans for a long time. Recently, several drugs and dietary supplements containing active components extracted from <em>Padina </em>have been commercially developed. Species of the <em>Padina </em>genus are quietly morphologically similar. Almost all previous studies of the <em>Padina </em>genus used the morphological identification method. This study presents the results of correlation analysis between morphological characteristics and the <em>rbc</em>L marker in the identification of <em>Padina </em>seaweed samples collected at Hon Thom, Phu Quoc, Kien Giang province (HTO), Vietnam. The phylogenetic tree and genetic distance between HTO with references showed the samples belonging to<em> Padina australis. </em>Thus, identification methods based on genetic markers and morphology on HTO seaweed samples were consistent.</p>Thu Hue Huynh Thi Dinh Phong VuBich Ngoc Nguyen Thi Thanh Xuan Nguyen ThiThanh Trung Do Thi Duc Tien Dam Le Tat Thanh
Copyright (c) 2024 Huynh Thi Thu Hue, Vu Dinh Phong, Nguyen Thi Bich Ngoc, Nguyen Thi Thanh Xuan, Do Thi Thanh Trung, Dam Duc Tien, Le Tat Thanh
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2024-06-232024-06-2346210.15625/2615-9023/20583Discrimination of Vietnamese species of the genus <i>Rhynocoris</i> (Hemiptera: Heteroptera: Reduviidae) with the utilization of integrative taxonomy
https://vjs.ac.vn/index.php/vjbio/article/view/20534
<p>The genus <em>Rhynocoris </em>Hahn, 1834 is one of the largest genera of the subfamily Harpactorinae. This genus consists of 144 described species widely distributed in the Afrotropical, Palearctic, Sino-Japanese, Oriental, and Nearctic Realms. There are three species, <em>Rhynocoris fuscipes </em>(Fabricius, 1787), <em>Rhynocoris marginellus </em>(Fabricius, 1803), <em>Rhynocoris mendicus </em>(Stål, 1867) recorded in Vietnam. In this study, we attempted to re-examine the <em>Rhynocoris </em>species collected from Vietnam based on external morphology, genital morphology, and COI phylogeny to reveal the species delimitation of this genus in Vietnam. As a result, the independence of the three <em>Rhynocoris </em>species from Vietnam was confirmed. Moreover, <em>R. mendicus </em>was revealed as being a polymorphic species with two intraspecific morphological phenotypes.</p>Xuan Lam TruongNgoc Linh Ha Thanh Truc TruongDac Dai NguyenQuang Cuong NguyenKatsuyuki Eguchi
Copyright (c) 2024 Truong Xuan Lam, Ha Ngoc Linh, Truong Thanh Truc, Nguyen Dac Dai, Nguyen Quang Cuong, Katsuyuki Eguchi
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2024-06-232024-06-23462193210.15625/2615-9023/20534New distribution and host record of <i>Stenarella insidiator</i> (Smith, 1859) (Hymenoptera: Ichneumonidae: Cryptinae) from Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/19995
<p>The ichneumonid parasitoid <em>Stenarella insidiator </em>(Smith, 1859) is recorded for the first time from Vietnam based on the specimens collected from Tam Dao National Park in Vinh Phuc province, Na Hang district in Tuyen Quang province, and Bidoup-Nui Ba National Park in Lam Dong province. In addition, the wasp <em>Orancistrocerus aterrimus</em> (de Saussure, 1852) (Hymenoptera: Vespidae) is reported as a new host of this parasitoid. The parasitoid is described based on Vietnamese material with information of its overwintering in the wasp nest.</p>Thi Nhi PhamQuynh Nga Cao Thi Thi Hoa Dang
Copyright (c) 2024 Pham Thi Nhi, Cao Thi Quynh Nga, Dang Thi Hoa
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2024-06-232024-06-23462333810.15625/2615-9023/19995Chemical composition and larvicidal activity of essential oil from leaves of <i>Eucalyptus robusta</i>
https://vjs.ac.vn/index.php/vjbio/article/view/19644
<p>Essential oil (EO) from leaves of <em>Eucalyptus robusta</em> was extracted by hydrodistillation, and analyzed the chemical composition using gas chromatography- Flame ionization detector (GC-FID), and gas chromatography/mass spectrometry (GC/MS). Thirty constituents from leaf EO were identified accounting for 97.48% of the total composition of EO. Monoterpene hydrocarbons were the major chemical classes (83.34%) in which 1,8-cineole (29.23%), <em>α-</em>pinene (18.58%), <em>α</em>-phellandrene (14.05%) and <em>β</em>-pinene (6.40%) were the main components. The larvicidal activity test against <em>Culex quinquefasciatus</em> showed that the essential oil from the leaves of <em>E. robusta</em> strongly inhibited this southern house mosquito with LC<sub>50</sub> values at 24 h and 48h to be 30.34 µg/mL and 28.77 µg/mL, respectively.</p>Hong Van Nguyen ThiThi Tuyen Tran Cao Bach Pham Thu Quynh DangThu Thuy Dinh ThiThanh Thuong VoGia Huy NgoQuoc Thong NguyenHuy Hung NguyenHuu Nghi Do
Copyright (c) 2024 Nguyen Thi Hong Van, Tran Thi Tuyen, Pham Cao Bach, Dang Thu Quynh, Dinh Thi Thu Thuy, Vo Thanh Thuong, Ngo Gia Huy, Nguyen Quoc Thong, Nguyen Huy Hung, Do Huu Nghi
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2024-06-232024-06-23462394510.15625/2615-9023/19644Comparison between scot and CBDP techniques in assessment genetic diversity and variation of two populations of bigfin reef squid (<i>Sepioteuthis lessoniana</i> d’Orbigny) in Con Dao and Phu Quoc islands, Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/19316
<p>The Start Codon Targeted Polymorphism (SCoT) and CAAT box-derived polymorphism (CBDP) techniques were used to analyze the genetic diversity and variation of two bigfin reef squid populations in waters surrounding the Con Dao and Phu Quoc islands of Vietnam for technical comparison. The two used techniques reflected different levels of pairwise genetic similarity among individuals depended on the investigated population. Gene differentiation (<em>G</em><sub>ST</sub>) between the two investigated populations was 0.0767 and 0.0373 leaded to the genetic distance between them was 0.0381 and 0.0228, and the gene flow was <em>N</em>m = 6.0195 and 12.9061 migrants per generation between the populations based on SCoT and CBDP techniques, respectively. Genetic variation within individuals of both populations (<em>WP</em>) played the key role in the total genetic variation of whole species in surveyed geographic regions with the distribution of 91.44% based on SCoT data and 93.76% based on CBDP data, the distribution of genetic variation among populations (<em>AP</em>) was small. For whole species in the surveyed region, the CBDP markers showed higher genetic diversity, while the SCoT markers reflected the differentiation and genetic distance between the two investigated populations better. Overall, the abilities to detect polymorphisms and the number of revealed loci using SCoT markers were better than using CBDP markers, while the ability to distinguish samples and the primer combination to detect the differences among investigated samples using CBDP markers were better than using SCoT markers, and the overall utility was comparable between these two marker systems. The results from this study prove that the CBDP technique can also be used in studies of animal population genetics.</p>Ngoc Trieu Le Thach Bich ThaiVan Long Nguyen
Copyright (c) 2024 Le Ngoc Trieu, Thai Thach Bich, Nguyen Van Long
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2024-06-232024-06-23462476110.15625/2615-9023/19316Profile of the gut microbial composition in <i>Apis mellifera</i> larvae collected in Ha Noi
https://vjs.ac.vn/index.php/vjbio/article/view/20165
<p>The gut microbiota plays a crucial role in food digestion, enhances the host's immune system, and against pathogens. Numerous studies have been conducted on the microbiota of insects in general and honeybees in particular. However, studies have primarily focused on adult honeybees, with fewer studies dedicated to larvae. Despite being within the hive, honeybee larvae still possess their distinct microbiota. To gain a deeper understanding of the microbiota in the larvae of <em>Apis mellifera</em> honeybees, the larva from honeybee colonies collected in Ha Noi, Vietnam was investigated. Next-generation sequencing (NGS) targeting the 16S rRNA gene was employed for microbiome analysis. Results revealed the presence of 5 phyla including Proteobacteria (70.43%), Actinobacteria (1.16%), Firmicutes (20.87%), Bacteroidetes (2.72%), and Chloroflexi (2%). Representative genera included <em>Bombella</em> (29.97%), <em>Lactobacillus</em> (14.91%), <em>Gilliamella</em> (9.59%), <em>Frischella</em> (4.69%), <em>Snodgrassella</em> (3.85%), and <em>Marinobacter</em> (1.21%). Further characterized species composition in the sample we identified the prevalence of <em>Bifidobacterium intestini </em>(29.96%), <em>Gilliamella apicola</em> (8.08%), <em>Frischella perrara</em> (4.55%), <em>Lactobacillus kimbladii</em> (2.85%), <em>Lactobacillus plantarum</em> (2.80%), <em>Snodgrassella alvi</em> (2.77%), <em>Lactobacillus mellis</em> (2.59%), <em>Lactobacillus_</em>uc (unclassified or not yet classified to species, 2.19%), <em>Lactobacillus kunkeei</em> (1.43%), and <em>Lactobacillus melliventris</em> (1.31%). Understanding these microbial dynamics is crucial for developing strategies to support honeybee health and mitigate the challenges posed by factors, such as pesticides, environmental pollution, and honeybee diseases.</p>Van Quyen DongThuy Duong Bui Thi Thi Lanh PhamThi Hoa NguyenQuang Huy NguyenThi Thu HaHong Thai Pham
Copyright (c) 2024 Dong Van Quyen, Bui Thi Thuy Duong, Pham Thi Lanh, Nguyen Thi Hoa, Nguyen Quang Huy, Ha Thi Thu, Pham Hong Thai
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2024-06-232024-06-23462637010.15625/2615-9023/20165Isolation and properties of endophytic bacteria and actinomycetes of <i>Catharanthus roseus</i> (L) G. Don grown in Nha Trang, Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/18984
<p>Endophytic microbes of medicinal plants are known to involve the synthesis of several bioactive compounds, which promote plant growth and resistance to diseases. In order to investigate endophytes in the important medicinal plant <em>Catharanthus roseus</em>, 16 endophytic microorganism strains were isolated from root samples of <em>C. roseus</em> var. <em>roseus</em> and <em>C. roseus</em> var. <em>ocellatus</em> naturally growing in coastal areas of Nha Trang, Vietnam. Based on morphological characteristics and 16S rDNA gene marker sequences, four actinomycetes of <em>Streptomyces</em> and <em>Microbiospora</em> genera and twelve bacterial strains belonging to <em>Bacillus, Enterobacter, Pseudomonas, Panenibacillus</em> and <em>Rhizobium</em> genera were identified. Analysis of the extracellular enzyme activities of actinomycetes strains indicated that <em>Streptomyces</em> strains produced proteases, cellulases, xylanases and amylases and <em>Microbiospora</em> strains exhibited protease and cellulase activities. The results demonstrated the diversity of endophytes in the roots of <em>C. roseus</em> plants and their potential extracellular enzyme activities for further application.</p>My Linh TranThi Hoe PhamChi Mai NguyenKhac Ban NinhHuong Giang VuTuong Van Nguyen
Copyright (c) 2024 Tran My Linh, Pham Thi Hoe, Nguyen Chi Mai, Ninh Khac Ban, Vu Huong Giang, Nguyen Tuong Van
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2024-06-232024-06-23462718210.15625/2615-9023/18984Screening of novel conopeptide for mosquitocidal activity against lethal mosquitoes (<i>Anopheles stephensi, Aedes aegypti</i>)
https://vjs.ac.vn/index.php/vjbio/article/view/20070
<p>Mosquitoes are carriers of various diseases that result in millions of human deaths annually. However, the use of chemical mosquitocides has led to significant concerns, such as adverse effects on the environment, human health, and insecticide resistance. As a result, there is a pressing need for eco-friendly alternatives. This study aimed to identify potential mosquitocidal conopeptides from cone snail venoms targeting two lethal mosquito species, <em>Anopheles stephensi </em>and<em> Aedes aegypti</em>. Eleven <em>Conus</em> species were collected from Nha Trang Bay and their crude venoms were dissected and collected. Through cell survival and toxicity assays on mosquito larvae, five crude venoms were identified to have inhibitory effects. Further investigations involved fractionating these five crude venoms and testing them for cell cytotoxic activity were conducted. Four fractions from <em>Conus bandanus</em> venom, named CB37, CB39, CB41, and CB43, showed significant cytotoxic activity against cell survival. Other fractions from different <em>Conus</em> venoms also exhibited some cytotoxic activity at high concentrations but were not prioritised for further investigation. Toxicity experiments on adult mosquitoes revealed that the CB41 fraction had the most potential, with an IC<sub>50</sub> of 30 μM. Additionally, this CB41 compound is a peptide in nature and was found to have a native mass of 3332.1 Da and three disulphide bridges. These results could deduce this long-chain peptide possessing a compact structure. To our knowledge, the conopeptide CB41 is reported first time to have mosquitocidal activity.</p>Bao NguyenKhanh Vinh Phan ThiVan Suu Nguyen Jean-Pière LE CAER
Copyright (c) 2024 Nguyen Bao, Phan Thi Khanh Vinh, Nguyen Van Suu, Jean-Pière LE CAER
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2024-06-232024-06-23462839210.15625/2615-9023/20070Analysis of genetic diversity of Ven dog breed based on microsatellite markers
https://vjs.ac.vn/index.php/vjbio/article/view/20446
<p>Microsatellite (MS) is a genetic marker widely used in the studies of pedigree, individual identification, gene mapping, and genetic diversity within and between populations. The genetic diversity of the indigenous Ven dog breed, along with two imported dog breeds, the Berger and Poodle dogs raised in Vietnam, was analyzed based on seven microsatellite markers. A total of 32 alleles, an average number of alleles/loci of 4.6 were observed across 80 samples of the three dog breeds. The overall polymorphic information content (PIC) was 0.67 representing the quality of selected MS markers. Genetic diversity indices (Ho, He, Fit, Fst) showed the phenomenon of inbreeding between individuals in the Ven dog population. The genetic similarity level and phylogenetic tree also reasonably reflect the genetic relationship between the three analyzed dog breeds, in which the Ven dog showed a higher genetic distance compared to two imported dog breeds.</p>Dieu Thuy Nguyen ThiCong Trieu LePhuong Loan Huynh Thi Tra Mi Bui ThiHuy Tuong NguyenAnh Khoa Do Vo
Copyright (c) 2024 Nguyen Thi Dieu Thuy, Le Cong Trieu, Huynh Thi Phuong Loan, Bui Thi Tra Mi, Nguyen Huy Tuong, Do Vo Anh Khoa
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2024-06-232024-06-234629310010.15625/2615-9023/20446Notes on genus <i>Cybister</i> Curtis, 1827 (Coleoptera: Dytiscidae) with the first records of <i>Cybister danxiaensis</i> Zhuo-Yin Jiang and <i>Cybister convexus</i> Sharp from Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/20535
<p>The genus <em>Cybister</em> Curtis, 1827 is reviewed for the fauna of Vietnam. The 5 species are diagnosed with illustrated habitus, leg, and male genitalia. Additional measurement data, and an updated identification key for all species are provided. Two species <em>Cybister convexus</em> Sharp, 1882, and <em>Cybister danxiaensis </em>Zhuo-Yin Jiang, 2023, are recorded for the first time in Vietnam.</p>Quang Cuong NguyenThanh Manh NguyenThi Giang PhanRyndevich SergeyXuan Lam Truong
Copyright (c) 2024 Nguyen Quang Cuong, Nguyen Thanh Manh, Phan Thi Giang, Ryndevich Sergey, Truong Xuan Lam
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2024-06-232024-06-2346210112010.15625/2615-9023/20535Antimicrobial and cytotoxic potential of endophytic actinomycetes isolated from <i>Cinnamomum cassia</i> Presl in Lai Chau Vietnam
https://vjs.ac.vn/index.php/vjbio/article/view/20547
<p>New antimicrobials are urgently needed to combat the threat of multidrug-resistant bacteria worldwide. Our study aimed to access the antimicrobial and cytotoxic profiles of endophytic actinomycetes associated with <em>Cinnamomum cassia</em> Presl taken from a mountainous region in the Northwest of Vietnam. The antimicrobial activity, capability for anthracycline-like compounds production and presence of secondary metabolite-biosynthetic genes were consequently determined. Finally, the cytotoxicity of antibiotic-producing actinomycetes was carried out towards various cancer cell lines. A total of 81 actinomycetes were recovered from different organs (roots, stems, leaves) of <em>Cinnamomum cassia</em>, of which 20/81 isolates exhibited antimicrobial activities against at least one of nine microbial strains. The analysis of 16S rRNA genes indicated that antibiotic-producing isolates were grouped into 4 genera <em>Streptomyces, Micromonospora, Saccharothrix, </em>and<em> Microbacterium</em>, among which <em>Streptomyces</em> was the most prevalent. The presence of biosynthetic genes <em>pks</em>-I, <em>pks</em>-II or <em>nrps </em>was detected in 17/20 of isolates. Five strains of <em>Streptomyces griseorubens</em> LCQ8, <em>Streptomyces variabilis</em> LCQ43, <em>Streptomyces californicus</em> LCQ44, <em>Streptomyces fragilis</em> LCQ75, and <em>Streptomyces beijiangensis</em> LCQ77 exhibited broad-spectrum antimicrobial activity against various pathogens with the MIC values ranging from 16 to 256 µg/mL. Furthermore, characterized strains showed considerable cytotoxicity against MCF-7 cell lines with a 50% inhibition concentration of crude culture extracts of less than 30 µg/mL. The findings demonstrated that <em>Streptomyces</em> species isolated from <em>Cinnamomum cassia</em> in mountainous regions hold the potential for growth inhibition of human disease agents.</p>Ngoc-Tung Quach Thi-Hanh Nguyen Vu Quyet Tien PhiQuang Huy Nguyen
Copyright (c) 2024 Quach Ngoc-Tung, Vu Thi-Hanh Nguyen, Quyet Tien-Phi, Nguyen Quang Huy
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2024-06-232024-06-2346212113110.15625/2615-9023/20547Genomic insights into multidrug-resistance and virulence in a vancomycin-resistant <i>Staphylococcus aureus</i> strain VR480
https://vjs.ac.vn/index.php/vjbio/article/view/20722
<p>Vancomycin-resistant <em>Staphylococcus aureus </em>(VRSA), a “high priority antibiotic-resistant pathogen”, is emerging and threatening global health. Nevertheless, molecular mechanisms associated with virulence and multidrug resistance in VRSA are not fully investigated particularly in low- and middle-income countries. Here, for the first time, the complete genome of a VRSA strain VR480 isolated from a Vietnamese patient was generated by the combination of long- and short-read sequencing technologies. The VRSA strain VR480 was a multidrug-resistant phenotype with resistance to at least one antibiotic belonging to beta lactams, quinolones, lincomycin, oxazolidinones, tetracyclines, glycylcyclines, macrolide/lincosamide/streptogramin, nitrofurans, rifamycins, sulfonamides and glycopeptides. This strain was classified as vancomycin resistance (MIC ≥ 32 μg/mL). VRSA strain VR480 belonged to sequence type ST2779 and carried the SCCmec type II(2A). The VRSA strain VR480 genome contains five resistance mutations in genes<em>. gyr</em>A S84L, <em>par</em>C S80F, <em>par</em>E D432N, <em>fus</em>A L461K and <em>glp</em>T W355Stop, and eleven antibiotic resistant genes including <em>mec</em>A, <em>mec</em>R, <em>mec</em>I, <em>tet</em>M, <em>tet</em>38, <em>mep</em>A, <em>lmr</em>S, <em>ant</em>(9), <em>erm</em>A, <em>fos</em>B and <em>cat</em>A. This strain possesses various virulence factors associated with adherence, biofilm formation, colonization, invasion, anti-phagocytosis and toxicity that promote the infection and pathogenesis. Protein interaction network analysis revealed five clusters consisting of known and putative virulence proteins. Furthermore, epimerase, EssC, IcaA, SplA and Ssl1 were the key proteins within each cluster. This study raises a warning about the circulation and dissemination of VRSA in Vietnam. The key proteins would be potential targets for the development of anti-virulent agents to combat the VRSA infection.</p>Quang Huy NguyenThai Son Nguyen Uyen Thu Nguyen ThaiThuy Duong Nguyen Thanh Tam Tran Thi
Copyright (c) 2024 Nguyen Quang Huy, Nguyen Thai Son, Nguyen Thai Uyen Thu, Nguyen Thuy Duong, Tran Thi Thanh Tam
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2024-06-232024-06-2346213314610.15625/2615-9023/20722