TY - JOUR AU - Doanh, Pham Ngoc AU - Hien, Hoang Van AU - An, Pham Thanh AU - Tu, Luu Anh PY - 2015/09/18 Y2 - 2024/03/29 TI - Development of lung fluke, Paragonimus heterotremus, in rat and mice, and the role of paratenic host in its life cycle JF - Academia Journal of Biology JA - AJB VL - 37 IS - 3 SE - Articles DO - 10.15625/0866-7160/v37n3.6168 UR - https://vjs.ac.vn/index.php/vjbio/article/view/6168 SP - 265-271 AB - <p>Lung fluke, <em>Paragonimus heterotremus</em>, has been identified as the important pathogen for human paragonimiasis in Vietnam. Eating under cooked mountain crabs, which are contaminated with <em>P. heterotremus</em> metacercariae, is confirmed as the route of infection. In this study, we identified the role of paratenic host in the life cycle of <em>P. heterotremus</em> by experimental infection to house rat (<em>Rattus tanizumi</em>) and mice BALB/c, and then transferred to cats. The results showed that <em>P. heterotremus</em> metacercariae developed to adults in the lungs of rats. In contrast, they remain as juvenile worms in liver and muscles of mice. These juveniles developed to adults when they were transferred to cats, confirming that mice serve as the role of paratenic hosts in the life cycle of <em>P. heterotremus</em> in Vietnam. Thus, investigation for natural paratenic hosts of <br /> <em>P. heterotremus </em>is necessary, and not eating uncooked/undercooked meat of other animals in addition to mountain crabs should be added to prevention of paragonimus infection. Development of different size metacercariae of <em>P. heterotremus</em> in rats and mice were also discussed herein.</p> ER -