@article{Ngoc Mai_Ha_Thom_Hong_2013, title={Initial studies on squalene from some marine microalgae isolated in Vietnam}, volume={35}, url={https://vjs.ac.vn/index.php/vjbio/article/view/3386}, DOI={10.15625/0866-7160/v35n3.3386}, abstractNote={<p>Squalene is a highly unsaturated aliphatic hydrocarbon and belongs to the triterpene group of oils. Squalene is the last metabolite preceding sterol ring formation in the biosynthetic cholesterol pathway. It is normally used in its natural form as a moisturizing or emollient agent in pharmaceuticals and cosmetic preparations. More importantly, it is a potential oxidation inhibitor; it can protect cell against free radicals, strengthen the body’s immune system and decrease the risk for various cancers. In this study, we presented the results of initial research on squalene from seven marine microalgal species isolated in Vietnam coasts. Based on colorimetric method, squalene content in these microalgae was determined.<em> Schizochytrium mangrovei </em>reached the highest squalene content of 122 mg/g. Squalene content of 21.090 mg/g for <em>Thraustochytrium mangrovei</em>, 6.300 mg/g for <em>Dunaliella tetiolecta</em>, 9.700 mg/g for<em> Isochrysis galbana</em>, 0.193 mg/g<em> Nannochloropsis</em> <em>oculata</em>, 1.850 mg/g for<em> Tetraselmis convolutae</em> and 3.300 mg/g for <em>Chlorella</em> <em>vulgaris</em> were obtained. Moreover, thin layer chromatography and high performance liquid chromatography methods were successfully applied to the determination of squalene in <em>S. mangrovei</em>. The squalene content of <em>S. mangrovei</em> analysed by TLC and HPLC reached 12.630 mg/g of nonsaponifiable lipid, 0,405 mg/g of total lipid and 0,203 mg/g of dry biomass.<strong></strong></p>}, number={3}, journal={Academia Journal of Biology}, author={Ngoc Mai, Dinh Thi and Ha, Nguyen Cam and Thom, Le Thi and Hong, Dang Diem}, year={2013}, month={Oct.}, pages={333–341} }