@article{Son_Huy_Tram_Cang_Chi_Dai_Thanh_Han_Han_Long_2020, title={Evaluating the effects of simulated microgravity on mouse fibroblast}, volume={42}, url={https://vjs.ac.vn/index.php/vjbio/article/view/14919}, DOI={10.15625/2615-9023/v42n4.14919}, abstractNote={<p>The present study investigated how mouse fibroblasts changed under microgravity (SMG) conditions (< 10<sup>-3</sup> G) simulated by 3D clinostat. Results showed that SMG condition markedly reduced the proliferation of mouse fibroblasts, significantly reducing the nuclear area and intensity. Compared to the control group, the mouse fibroblasts ratio of the SMG group was higher in the G0/G1 phase but lower in the S phase and G2/M phase. The ratios of early and late apoptotic cells were also higher in the SMG group. The mouse fibroblasts under SMG conditions exhibited a reduction of β-Actin and α-Tubulin 3 expressions compared to the control group. These results suggested that the SMG condition diminished the proliferation and downregulated cytoskeletal protein expression of mouse fibroblasts.</p><p><strong> </strong></p>}, number={4}, journal={Academia Journal of Biology}, author={Son, Hoang Nghia and Huy, Hoang Nguyen Quang and Tram, Tran Thi Bich and Cang, Ly Ngoc and Chi, Ho Nguyen Quynh and Dai, Truong Xuan and Thanh, Le Ngoc Phuong and Han, Truong Thi and Han, Nguyen Thai Minh and Long, Le Thanh}, year={2020}, month={Oct.} }