TY - JOUR AU - Anh, Nguyen Hoang AU - Park, SeonJu AU - Trang, Do Thi AU - Yen, Duong Thi Hai AU - Tai, Bui Huu AU - Yen, Pham Hai AU - Kiem, Phan Van AU - Chinh, Pham The AU - Nhiem, Nguyen Xuan PY - 2022/04/21 Y2 - 2024/03/29 TI - Genus Mallotus (Euphorbiaceae): A review on traditional medicinal use, phytochemistry and biological activities JF - Vietnam Journal of Science and Technology JA - Vietnam J. Sci. Technol. VL - 60 IS - 2 SE - Review DO - 10.15625/2525-2518/16634 UR - https://vjs.ac.vn/index.php/jst/article/view/16634 SP - 141-174 AB - <p><em>Ethnopharmacological relevance</em>: The genus <em>Mallotus</em> (Euphorbiaceae family) includes 124 accepted names and distributes in tropical and sub-tropical regions. Some <em>Mallotus </em>species are used in traditional medicines for the treatment of chronic hepatitis, enteritis stomach, disorders, cholelithiasis, anti-cancer, &nbsp;gastric, and duodenal ulcers.</p><p><em>Aim of the study</em>: According to the Scifinder database, this is the first review study that focuses on the phytochemistry and pharmacology of <em>Mallotus</em> genus (17 <em>Mallotus</em> species) to understand the link between the traditional medicinal uses, phytochemistry, and bioactivities. Thus, they provides a scientific fundamental for further research in the phytochemical and pharmacological activities of their species.</p><p><em>Materials and methods</em>: Information about the<em> Mallotus</em> genus was collected using various databases, such as Web of Science, SciFinder, PubMed, Sci-hub, Google Scholar, Wiley, Elsevier, ACS publications, and SpringerLink between 1978 and 2021. Plant names were validated by “The Plant List” (<a href="http://www.theplantlist.org">www.theplantlist.org</a>).</p><p><em>&nbsp;Results</em>: Up to now, total 325 compounds were reported from <em>Mallotus </em>species, including phloroglucinols, steroids, coumarins, benzopyrans, flavonoids, chalcones, galics, and bergenins. The extracts and phytochemical constituents of&nbsp;<em>the Mallotus&nbsp;</em>genus are a rich source of biologically active, including anti-cancer, anti-inflammatory, immunoregulatory, antioxidant, antibacterial, antifungal, anti-virus, and other activities.</p><p><em>Conclusions</em>: The review indicated that the <em>Mallotus </em>genus is a promising source of biological activities compounds, special anti-cancer chromanes. The results of this review confirm the great potential of <em>Mallotus</em> species. Thus, it will be helpful for further research in the phytochemistry and pharmacology of the<em> Mallotus</em> genus.</p> ER -