TY - JOUR AU - Tuong, Tran Duc AU - Chu, Duong Xuan AU - Dieu, Bui Thi Minh PY - 2020/04/07 Y2 - 2024/03/29 TI - Antioxidant activity of fruiting body extracts from Pycnoporus sanguineus mushroom JF - Vietnam Journal of Science and Technology JA - Vietnam J. Sci. Technol. VL - 58 IS - 2 SE - Natural Products DO - 10.15625/2525-2518/58/2/14400 UR - https://vjs.ac.vn/index.php/jst/article/view/14400 SP - 143-151 AB - The objective of the this study is to provide an <em>in vitro</em> evidence for the potential antioxidant activity of the ethanolic and aqueous extracts from fruiting bodies of <em>Pycnoporus sanguineus</em> mushroom via DPPH free radical scavenging and lipid peroxidation inhibition assays. DPPH free radical and lipid peroxidation inhibitory activities of ethanolic and aqueous extracts from fruiting bodies of <em>P. sanguineus</em> were examined in a dose-response manner. Ascorbic acid and trolox were was used as a positive control for these assays and the results showed that the ethanolic extract of <em>P. sanguineus</em> possessed strong inhibitory activity on DPPH free radical and lipid peroxidation with IC<sub>50</sub> values of 196.68 and 975.84  μg/mL, respectively. The aqueous extract also exhibited moderate activity against DPPH free radical and lipid peroxidation with IC<sub>50</sub> values of 322.03 and 1311.24 μg/mL, respectively. Which was significantly lower than that of ascorbic acid and trolox with IC<sub>50</sub> values of 55.00 and 886.68 μg/mL, respectively. The degree of DPPH free radical and lipid peroxidation inhibition was correlated with the dose of inhibitors. Based on the obtained results, the <em>P. sanguineus</em> mushroom possesses high potential in antioxidant activity and could be a potential source of natural antioxidants in food and pharmaceutical applications. ER -