@article{Ha_Salvaraja_Long_Quang_Nghi_Wook_Thuy_2019, title={Synthesis of two new hydroximinosteroids from cholesterol and their biological evaluation}, volume={57}, url={https://vjs.ac.vn/index.php/jst/article/view/13809}, DOI={10.15625/2525-2518/57/5/13809}, abstractNote={A simple and efficient synthesis of two new hydroximinosteroidal derivatives (<strong>11</strong>, <strong>13</strong>) from cholesterol was described. The cytotoxicity of these compounds, their intermediates were evaluated on human cancer cell lines including Hep-G2, HeLa and T98G. Compound <strong>13</strong> presented a potent antiproliferative effect to T98G cancer cell at 2.9 mM of IC<sub>50</sub>. In addition, the antimicrobial assay showed that two new oximes <strong>11</strong> and <strong>13</strong> were active against <em>E. coli</em> and <em>S. aureus</em> strain (MIC :50 mg/mL).}, number={5}, journal={Vietnam Journal of Science and Technology}, author={Ha, Dinh Thi and Salvaraja, Baskar and Long, Pham Quoc and Quang, Ngo Dai and Nghi, Do Huu and Wook, Lee Jae and Thuy, Tran Thi Thu}, year={2019}, month={Oct.}, pages={527–538} }