Synthesis co(benzenesulfonamide serinol-lactide) for preparation of the ph-sensitive hydrogel

Authors

  • Vu Viet Linh Nguyen Faculty of Applied Sciences, Ho Chi Minh City University of Technology and Education, 1 Vo Van Ngan Street, Thu Duc City, Ho Chi Minh City, Viet Nam
  • Dai Phu Huynh Faculty of Materials Technology, HCMC University of Technology, VNU-HCM, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/16375

Keywords:

benzenesulfonamide serinol, lactide, the ring-opening reaction

Abstract

The pH-sensitive hydrogel based on polyurethanes is one of the most popular biodegradable copolymers that have been used in drug carrier applications. Polyurethanes containing sulfonamide groups exhibit sensitivity to changes in pH environment because they can receive and donate cationic hydrogens. In this research, the co(benzenesulfonamide serinol-lactide), named Co(BSSe-LA), was synthesized based on the ring-opening reaction of lactide and hydroxyl groups of benzenesulfonamide serinol (BSSe). The influence of reaction time and content (wt.%) of stannous octoate catalyst on the reaction efficiency of Co(BSSe-LA) was investigated. Proton nuclear magnetic resonance (H1NMR) and Fourier transform infrared spectroscopy (FTIR) analyses confirmed the successful formation of BSSe and Co(BSSe-LA). Besides, the results show that the reaction efficiency of Co(BSSe-LA) increased when the reaction time and the stannous octoate concentration increased. The reaction efficiency of Co(BSSe-LA) was 33.67 % with reaction parameters including catalyst content of 1.2 wt.%, reaction time of 24 hours and BSSe/LA molar ratio of 1/2. Co(BSSe-LA) was prepared for polymerization of polyurethane and fabrication of pH-sensitive hydrogel. Furthermore, the product can be decomposed easily in aqueous medium thanks to the ester group of lactide. This hydrogel copolymer may be potential as an injectable hydrogel for the controllable drug and protein delivery system.

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Published

2022-03-11

How to Cite

[1]
V. V. L. . Nguyen and D. P. Huynh, “Synthesis co(benzenesulfonamide serinol-lactide) for preparation of the ph-sensitive hydrogel”, Vietnam J. Sci. Technol., vol. 59, no. 6A, pp. 60–68, Mar. 2022.

Issue

Section

International Symposium on Materials Science and Engineering - ISMSE