• Nguyễn Thị Linh Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Nguyễn Tấn Tài Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Trần Đỗ Đạt Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Phan Lê Thảo My Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Ngô Thị Thùy Linh Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Nguyễn Thị Kim Ngân Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Vương Hoài Thanh Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Nguyễn Đức Việt Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Đặng Hoàng Bảo Ngọc Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Hoàng Minh Nam Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Mai Thanh Phong Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM
  • Nguyễn Hữu Hiếu Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM




Ganoderma lucidum, ultrasound – assisted extraction, response surface methodology, triterpenoids


An ecofriendly ultrasound – assisted extraction (UAE) method was developed for the triterpenoids extraction from Vietnamese red Ganoderma lucidum (G. lucidum). The appropriate kind of solvent for extraction procedure was selected as ethanol based on the yield of triterpenoids obtained, followed by the investigation of four single factors including solvent-to-material ratio, extraction temperature, extraction time, and ultrasonic power. According to the result of single factor experiments, optimal extraction conditions were determined with solvent-to-material ratio of 30:1 mL/g, extraction temperature of 55 , extraction time of 60 min, and ultrasonic power of 480 W. Under these conditions, UAE produced a highest triterpenoids yield of 9.7976  0.334 mg/g by using ultraviolet-visible spectroscopy (UV-Vis) analysis. Extract obtained from UAE method showed better antioxidant activity compared to that of ascorbic acid with the half-maximal inhibitory concentration values were of 32.685 and 6.902 µg/mL, respectively. As a result, triterpenoids extracted from G. lucidum could be considered as a promising antioxidant agent.


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The 7th National Workshop on Research and Development of Natural Products