PREPARATION AND CHARACTERIZATION OF CHITOSAN/ALGINATE/GINSENOSIDE RB1 NANOPARTICLES
Keywords:ginsenoside Rb1, functional groups, size distribution, drug release
This work is focused on preparation and characterization of chitosan/alginate/ginsenoside Rb1 nanoparticles prepared by ionic gelation method with ginsenoside Rb1 content of 3, 5 and 7 wt.% in comparison with total weight of chitosan and alginate. Some methods including to Infrared Spectroscopy (IR), Dynamic Light Scattering (DLS), and Field Emission Scanning Electron Microscopy (FESEM) and Ultraviolet-Visible spectroscopy (UV-Vis) methods were used to determine the functional groups, size distribution, morphology and ginsenoside Rb1 release content from the chitosan/alginate/ginsenoside Rb1 nanoparticles. Ginsenoside Rb1 was dispersed regularly in chitosan/alginate matrix. The particle size of chitosan/alginate/ginsenoside Rb1 nanoparticles was reduced as increasing the ginsenoside Rb1 content. The ginsenoside Rb1 release content from the chitosan/alginate/ginsenoside Rb1 nanoparticles in simulated body fluids was also evaluated and discussed.
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