MICROWAVE-ASSISTED THE CLAISEN-SCHMIDT CONDENSATION BETWEEN ARYLMETHYL KETONES AND ARYL ALDEHYDES CATALYZED BY CU(OTF)2 UNDER SOLVENT-FREE CONDITIONS. SYNTHESIS OF CHALCONES
AbstractAn environmentally friendly and high yield method for the Claisen-Schmidt condensation has been investigated. A Mixture of an arylmethyl ketone and an aldehyde was irradiated in a microwave reactor for 20 minute using Cu(OTf)2 as catalyst in solvent-free conditions. 12 chalcones were synthesized in moderate to excellent yields (67-91%). This is the first time the Claisen-Schmidt condensation with Cu(OTf)2 under microwave irradiation was reported.
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