Triterpenoids from a Vietnamese medicinal plant Selaginella rolandi-principis Alston and their PTP1B Inhibitory activity
AbstractAs part of an ongoing search for new protein tyrosine phosphatese 1B (PTP1B) inhibitors from medicinal plants, the methanol extract of Selaginella rolandi-principis Alston was found to possess PTP1B inhibition. Thus, bioassay-guided separation of this active extract led to the identification of four compounds (1‒4) as active principles. Their chemical structures were elucidated by extensive analysis of spectroscopic and physicochemical data. Among the isolates, compounds 1–3 exhibited potential inhibitory activities with IC50 values of 18.8 ± 0.7, 5.6 ± 0.9, and 28.4 ± 1.2 µM against PTP1B. In this assay, ursolic acid as positive control displayed an IC50 value of 3.46 ± 0.07 µM.
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