CHOLESTANE-TYPE STEROIDS FROM THE OCTOCORAL Verrucella corona

Authors

DOI:

https://doi.org/10.15625/2525-2518/56/4A/12754

Keywords:

Verrucella corona, octocoral, steroid, cytotoxic activity

Abstract

Using various chromatographic separations, three cholestane-type steroids were isolated from the methanol extract of the octocoral Verrucella corona. Their structures were elucidated to be (22E)-cholesta-5,22-dien-3β-ol-7-one (1), trans-liagosterol (2), and guggulsterol-II (3), by detailed analysis of the 1D and 2D-NMR data as well as comparison with those reported. Among them, compound 2 showed significant cytotoxicity against eight human cancer cell lines as HepG2, HL-60, KB, LNCaP, LU-1, MCF7, SK-Mel2, and SW480.

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Published

2018-10-19

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Section

The 6th National Workshop on Research and Development of Natural Products