EFFECT OF POLYETHYLENE OXIDE ON PROPERTIES OF CHITOSAN/ALGINATE/LOVASTATINE COMPOSITES
Keywords:compatibilizer, PEO, Lovastatin, drug release, solution method.
In this work, polyethylene oxide (PEO) was used as a compatibilizer to improve compatibility of chitosan (CS) and alginate (AG) in CS/AG composites loading lovastatine (LS). The CS/AG/PEO/LS composites were prepared by solution method with the ratio of AG/CS and LS content fixed at 4/1 and 10 wt.% (in comparison with the total weight of CS and AG), respectively. The PEO content was changed 3, 5 and 10 wt.% as compared with AG+CS+LS weight. Thanks to presence of PEO, the CS/AG/LS composites have more regular structure as well as higher loading capacity and better drug release control. The effect of PEO on structure and morphology of CS/AG/PEO/LS composites was evaluated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and differential scanning calorimetric (DSC) methods. The FTIR spectra of CS/AG/PEO/LS composites exhibited the peaks characterized for main groups in AG, CS, PEO and LS. The SEM images showed that LS in a bar shape can disperse more regularly in CS/AG/PEO/LS composites than that in the composite without PEO. The DSC diagrams expressed that the relative crystal degree of CS/AG/PEO/LS composites was smaller than that in CS/AG/LS composite. The influence of PEO content on the in-vitro drug release from the composites in pH 7.4 solution was also investigated.
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