ENZYMATIC PREPARATION OF MODULATED–BIODEGRADABLE HYDROGEL NANOCOMPOSITES BASED CHITOSAN/GELATIN AND BIPHASIC CALCIUM PHOSPHATE NANOPARTICLES
Keywords:chitosan, gelatin, horseradish peroxidase (HRP), hydrogel, collagenase.
In the study, injectable chitosan–4 hydroxyphenylacectamide acid (CHPA) and gelatin–tyramine (GTA)–based hydrogels were enzymatically prepared, in which could encapsulate biphasic calcium phosphate nanoparticles (BCP NPs) for enhancing bone regeneration. The in situ formation of hydrogel composite was varied from 35 to 80 seconds depending on concentration of H2O2. Collagenase–mediated biodegradation of the hydrogel composite could be modulated from 3 days to over one month depending on amount of the formulated CHPA. Live/dead cell viability assay indicated that the hydrogel composite enhanced bone marrow mesenchymal stem cells (MSCs). The obtained results show a great potential of the hydrogel composites for bone regeneration due to its adjustable biodegradation, biocompatibility and enhancement in new bone formation.
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