COMPARISON OF RADICALS SCAVENGING ACTIVITY OF EXOPOLYSACCHARIDES FROM CULTURED CORDYCEPS SPP. ISOLATED IN VIET NAM
Keywords:antioxidant, Cordyceps, cultured broth, EPS, exopolysaccharide.
Cordyceps is a well-known traditional medicine to heal various serious diseases for centuries. Besides, polysaccharides isolated from Cordyceps had demonstrated to exhibit potential bioactivities, especially antioxidant activity. Hence, this study concentrated on the antioxidant effects of exopolysaccharides (EPS) isolated from ten kinds of Cordyceps cultured broth. Consequently, Cordyceps sinensis cultured broth possessed the highest EPS as well as total carbohydrate content, but the nearly lowest protein content (2.75 g/l, 69.39 % and 1.01 % respectively). Most of EPSs exhibited potential radical - scavenging activities suggesting that EPSs would have been regarded as antioxidant resources. Nonetheless, the EPS from DL0067 possessed the highest ABTS radicals scavenging activity (IC50 value = 1026.70 ± 3.64 µg/ml) but low hydroxyl radicals scavenging activity (IC50 value > 5,000 µg/ml). The EPS from DL0075, in contrast, exhibited the highest hydroxyl radicals scavenging activity (IC50 value = 463.15 ± 26.19 µg/ml). All in all, the experiments were indicated higher antioxidant activities of EPS from Cordyceps isolated in Viet Nam than those from Cordyceps sinensis. These findings demonstrated that the antioxidant activities related to complexes of polysaccharides and proteins instead of only polysaccharide contents.
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