PTP1B INHIBITORY CONSISTUENTS FROM VIETNAMESE MEDICINAL PLANT SELAGINELLA TAMARISCINA
Keywords:Selaginella tamariscina, PTP1B inhibitors, biflavonoids, selaginellins, Quyen ba.
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the
treatment of type 2 diabetes and obesity. From the alcoholic extract of the aerial parts of
Selaginella tamariscina, four compounds including selaginellin (1), amentoflavone (2), β-
sitosterol (3), and scoparone (4) have been isolated and structurally elucidated by using
combined chromatographic and spectroscopic experiments. Among the isolates, selaginellin (1)
and amentoflavone (2), exhibited potential PTP1B inhibitory activities with IC50 values of 15.9 ±
0.6 and 7.4 ± 0.5 μM, respectively.
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