PTP1B INHIBITORY CONSISTUENTS FROM VIETNAMESE MEDICINAL PLANT SELAGINELLA TAMARISCINA

Authors

  • Nguyen Phi Hung Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 1H building, 18 Hoang Quoc Viet, Cau Giay, Hanoi

DOI:

https://doi.org/10.15625/2525-2518/54/2C/11882

Keywords:

Selaginella tamariscina, PTP1B inhibitors, biflavonoids, selaginellins, Quyen ba.

Abstract

Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the
treatment of type 2 diabetes and obesity. From the alcoholic extract of the aerial parts of
Selaginella tamariscina, four compounds including selaginellin (1), amentoflavone (2), β-
sitosterol (3), and scoparone (4) have been isolated and structurally elucidated by using
combined chromatographic and spectroscopic experiments. Among the isolates, selaginellin (1)
and amentoflavone (2), exhibited potential PTP1B inhibitory activities with IC50 values of 15.9 ±
0.6 and 7.4 ± 0.5 μM, respectively.

Downloads

Download data is not yet available.

Downloads

Published

2018-03-19

Issue

Section

Articles