SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A

Authors

  • Le Duc Anh Chemistry-Materials Institute, Institute of Military Science and Technology 17 Hoang Sam, Cau Giay, Hanoi

DOI:

https://doi.org/10.15625/2525-2518/54/2C/11880

Keywords:

murrayafoline A, N-alkylation, cytotoxicity, sesquiterpene, conjugate.

Abstract

Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 wereprepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylationreactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,LU, RD and Fl. The result showed that both compounds exhibited no activity against the testedcell lines.

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Published

19-03-2018

Issue

Section

Articles