SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A
Keywords:murrayafoline A, N-alkylation, cytotoxicity, sesquiterpene, conjugate.
AbstractTwo new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 wereprepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylationreactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,LU, RD and Fl. The result showed that both compounds exhibited no activity against the testedcell lines.
Download data is not yet available.