SECONDARY METABOLITES PRODUCED BY MARINE BACTERIRUM MICROMONOSPORA SP. (G068)

Authors

  • Cao Duc Tuan Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/2525-2518/54/2C/11875

Keywords:

Micromonospora sp., marine microorganisms, antibacteria, norharman, cyclic dipeptide.

Abstract

Nine compounds (1-9) were isolated and characterized from the culture broth of the marine
bacteria Micromonospora sp. (strain G068), which was isolated from sediment collected at Co
To – Quang Ninh. Their structures were determined by spectroscopic analysis including MS, 1D
NMR and 2D NMR, as well as by comparison with reported data in the literature. All
compounds were evaluated for their antimicrobial activities against a panel of clinically
significant microorganisms. Compounds 1, 6, and 9 selectively inhibited Escherichia coli with
MIC values of 128, 128 and 64 μg/mL, respectively.

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Published

2018-03-19

Issue

Section

Articles