STRUCTURAL CHARACTERISTICS AND ANTICOAGULANT ACTIVITY OF SULFATE POLYSACCHARIDE FROM THE BROWN ALGA SARGASSUM ALIQUALIUM
Keywords:sulfate polysaccharide, Sargassum aliqualium, structure, anticoagulant activity.
Four fractions of sulfate polysaccharide extracted from the brown alga Sargassum
aliqualium (Fucales, sargassaceae) were fractionated by using anion – exchange
chromatography. Their structural characteristics were determined by desulfation, methylation
and NMR spectroscopic methods. The results showed that four sulfate polysaccharides have
branched structure, their chemical compositions are galactose, fucopyranose, fucofuranose,
mannose, some other monosaccharides and sulfate groups in different positions. The sulfate
polysaccharides from Sargassum aliqualium showed anticoagulant activity and higher sulfate
content fraction has higher activity.
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