IN VITRO ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES OF FRACTIONATED EXTRACTS AND ISOLATION OF BIOACTIVE COMPONENTS FROM BREYNIA VITIS-IDAEA (BURM. F.) C. E. C. FISCHER LEAVES
Keywords:Breynia vitis-idaea, antioxidant activities, antibacterial activities, 6-O-benzoylarbutin.
This study investigated the antioxidant and antibacterial activities of ethyl acetate, nbutanol
and ethanol extracts of Breynia vitis-idaea (Burm.f.) C. E. C. Fischer leaves using in
vitro assays;and isolated bioactive compounds from the fractioned extract which showed the best
properties by column chromatography. All extracts showed significant radical scavenging
activities and exhibited antibacterial activities against Enterococcus faecalis, Staphylococcus
aureus and methicillin-resistant Staphylococcus aureus (MRSA). Ethyl acetate extracts showed
the highest free radical scavenging capacity with the IC50 values of 99.55 and 94.66 μg/ml (in
DPPH and ABTS assays, respectively) and exhibited MIC values of 1.5, 1 and 1 mg/ml against
the three bacteria, respectively. In addition, from ethyl acetate extracts, one pure compound has
been obtained and identified as 6-O-benzoylarbutin.
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