SOME TRITERPENOIDS AND STEROIDS FROM THE LICHEN LOBARIA ORIENTALIS, LOBARIACEAE.
Keywords:Lobaria orientalis, lichen, triterpenoid, steroid, HepG2, NCI-H460, HeLa, MCF-7.
Chemical investigation of the ethyl acetate extract of the lichen Lobaria orientalis,
Lobariaceae, collected in Vietnam, afforded six known compounds, including four triterpenoids,
zeorin (1), 16β-acetoxyhopane-6α,22-diol (2), retigeric acid A (3), retigeric acid B (4), together
with two steroids, ergosterol-5α,8α-peroxide (5) and cerevisterol (6). Their chemical structures
were elucidated by spectroscopic data analysis and comparison with those reported in the
literature. The cytotoxic activities of some compounds against liver hepatocellular carcinoma
(HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human
breast cancer (MCF-7) cell lines were evaluated. Compound 2 exhibited good cytotoxicity
against MCF-7 cancer cell line with IC50 value of 21.10 μg/mL. This is the first time compounds
(1), (2), (6) are reported in the Lobaria genus.
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