Ergostane steroids from <i>Aspergillus</i> sp. M904 in Vietnam

Thi Thanh Van Trinh; Mai Anh Nguyen; Van Nam Vu; Thuy Linh Nguyen; Thi Hong Minh Le; Brian T. Murphy; Thi Mai Huong Doan; Van Cuong Pham

doi:10.15625/1859-3097/22128

Author affiliations

Authors

Trinh Thi Thanh Van Institute of Marine Biochemistry, VAST, Vietnam
Nguyen Mai Anh Institute of Marine Biochemistry, VAST, Vietnam; Graduate University of Science and Technology, VAST, Vietnam
Vu Van Nam Institute of Marine Biochemistry, VAST, Vietnam
Nguyen Thuy Linh Institute of Marine Biochemistry, VAST, Vietnam
Le Thi Hong Minh Institute of Marine Biochemistry, VAST, Vietnam
Brian T. Murphy University of Illinois Chicago, Illinois 60612-7231, USA
Doan Thi Mai Huong Institute of Marine Biochemistry, VAST, Vietnam; Graduate University of Science and Technology, VAST, Vietnam
Pham Van Cuong Institute of Marine Biochemistry, VAST, Vietnam; Graduate University of Science and Technology, VAST, Vietnam

DOI:

https://doi.org/10.15625/1859-3097/22128

Keywords:

Aspergillus, steroid, ergostane, antimicrobial.

Abstract

Seven ergostane steroids were isolated from the cultures of Aspergillus sp. M904, an endophytic fungus isolated from the marine sediment sample collected at a depth of ten meters in Binh Dinh, Vietnam. These compounds include 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7α-diol (1), 5α,6α-epoxy-(22E,24R)-ergosta-8(9),22-diene-3β,7α-diol (2), ergosterol (3), ergosterol peroxide (4), 3β,5α,6α-trihydroxy-ergosta-7,22-diene (5), 3β,5α,9α-trihydroxy-ergosta-7,22-diene-6-one (6), 3β-hydroxy-5α,9α-epoxy-ergosta-7,22-dien-6-one (7). Their structures were identified through MS and NMR data analyses. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compounds 1–7 had inhibitory activity against from one to six tested strains with MIC values from 64–256 µg/mL.

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