Antimicrobial secondary metabolites from a marine-derived fungus <i>Penicillium</i> sp. OM07

Thi Dao Phi; Thuy Linh Nguyen; Van Nam Vu; Thi Quyen Vu; Mai Anh Nguyen; Thi Thu Huyen Vu; Thi Hong Minh Le; Van Cuong Pham; Thi Mai Huong Doan

doi:10.15625/1859-3097/19564

Author affiliations

Authors

Phi Thi Dao Institute of Marine Biochemistry, VAST, Vietnam
Nguyen Thuy Linh Institute of Marine Biochemistry, VAST, Vietnam https://orcid.org/0000-0002-1817-0687
Vu Van Nam Institute of Marine Biochemistry, VAST, Vietnam
Vu Thi Quyen Institute of Marine Biochemistry, VAST, Vietnam
Nguyen Mai Anh Institute of Marine Biochemistry, VAST, Vietnam
Vu Thi Thu Huyen Institute of Marine Biochemistry, VAST, Vietnam https://orcid.org/0000-0002-3211-5254
Le Thi Hong Minh Institute of Marine Biochemistry, VAST, Vietnam
Pham Van Cuong Institute of Marine Biochemistry, VAST, Vietnam; Graduate University of Science and Technology, VAST, Vietnam
Doan Thi Mai Huong Institute of Marine Biochemistry, VAST, Vietnam; Graduate University of Science and Technology, VAST, Vietnam https://orcid.org/0000-0003-3252-870X

DOI:

https://doi.org/10.15625/1859-3097/19564

Keywords:

Penicillium, diketopiperazine dimer, antimicrobial activity, ergosterol, marine sediment.

Abstract

Eight compounds, diketopiperazine dimer WIN 64821 (1), ergosterol peroxide (2), ergosterol (3), 3β,5α,9α-trihydroxyergosta-7,22-dien-6-one (4), 3,4-dihydroxy-6,7-dimethyl-quinolin-2-carboxylic (5), norhaman (6), dihydrocitrinin (7), and phenol A acid (8) were isolated and characterized from the culture broth of the marine-derived Penicillium sp. OM07 strain was isolated from sediment collecting at Son Cha, Hue, Vietnam. Their structures were determined by analyses of MS and NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Most showed high antifungal activity against Candida albicans ATCC10231 strain with MIC values ranging from 8 µg/mL to 256 µg/mL. All compounds had inhibitory activity against from one to three Gram-positive tested strains with MIC values from 64–256 µg/mL.

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