Sterols from Vietnamese marine sponge Tethya aurantium

Nguyen Thi Cuc, Dan Thi Thuy Hang, Bui Huu Tai, Nguyen Xuan Nhiem, Hoang Le Anh Tuan, Pham Hai Yen, Vu Van Doan, Chau Van Minh, Phan Van Kiem

Abstract


Chemical investigation on Vietnamese marine sponge Tethya aurantium resulted in the isolation of five sterols, including 5R,6R-epoxy-24R*-ethylcholesta-8-en-3β,7α-diol (1), 24-methylenecholesta-5-en-3β-ol (2), 24-norcholesta-5,22E-dien-3β-ol (3), 5α,8α-epidioxy-24R*-ethylcholesta-6-en-3β-ol (4), and 5α,8α-epidioxy-24S-methylcholesta-6,22E-dien-3β-ol (5). Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported literatures. Stereochemistry of C-24 in the side chain of isolated sterols was also discussed. This is the first study on chemical constituents from the sponge T. aurantium.

Keywords. Steroid, Tethya aurantium, Vietnamese sponge.


Keywords


Steroid, Tethya aurantium, Vietnamese sponge.